| generic name | brand name | drug class or drug category | general use |
| zafirlukast | Accolate | leukotriene inhibitor; antiasthmatic | for the prophylaxis and chronic treatment of asthma in adults and children |
| zalcitabine | Hivid | antiviral; reverse transcriptase inhibitor | human immunodeficiency virus (HIV) |
| zaleplon | Sonata | sedative hypnotic | to induce sleep; to treat insomnia |
| zanamivir | Relenza | neuraminidase inhibitor; antiviral | to treat both influenza A and influenza B; to prevent getting the flu |
| zidovudine | Retrovir | antiviral | human immunodeficiency virus (HIV) |
| zidovudine/abacavir/lamivudine | Trizivir | antiviral | human immunodeficiency virus (HIV) |
| zidovudine/lamivudine | Combivir | antiviral; reverse transcriptase inhibitor | human immunodeficiency virus (HIV) |
| zileuton | Zyflo CR | antiasthmatic; leukotriene inhibitor | for the prophylaxis and chronic treatment of asthma in adults and children |
| ziprasidone | Geodon | antipsychotic | mental disorders (schizophrenia, bipolar) |
| zoledronic acid (injection) | Reclast | bisphosphonate; bone resorption inhibitor | to treat osteoporosis and the Paget's disease of bone in men and women |
| zoledronic acid (injection) | Zometa | bisphosphonate; antihypercalcemic | to treat hypercalcemia of malignancy; to treat multiple myeloma and bone metastases of solid tumors |
| zolmitriptan | Zomig; Zomig-ZMT | selective 5-HT agonist; antimigraine | migraine headaches |
| zolpidem (oral) | Ambien; Ambien CR | sedative hypnotic | to induce sleep; to treat insomnia |
| zonisamide (oral) | Zonegran | anticonvulsant | to treat seizures in adults with epilepsy |